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Search for "controlled drug delivery" in Full Text gives 12 result(s) in Beilstein Journal of Organic Chemistry.
Switchable molecular tweezers: design and applications
Beilstein J. Org. Chem. 2024, 20, 504–539, doi:10.3762/bjoc.20.45
- their open conformation. This causes fluctuations and local defects in the packing of a bilayer (Figure 3), leading to membrane disruption and release of active components from within the vesicles [22]. Such concept makes these tweezers good candidates for controlled drug delivery. The group of F. Wang
Synthesis of a new water-soluble hexacarboxylated tribenzotriquinacene derivative and its competitive host–guest interaction for drug delivery
Beilstein J. Org. Chem. 2022, 18, 539–548, doi:10.3762/bjoc.18.56
- of SM, as confirmed by 1H NMR titration experiments. This host–guest competitive substitution system may have potential applications in controlled drug delivery. Experimental General information. All commercially available reagents were used as received unless otherwise specified. Anhydrous solvents
- -containing amphiphile (trans-AZO) to produce the TBTQ-C6-trans-AZO supra-amphiphile by host–guest interactions in water. The supra-amphiphile was further self-assembled into photo and pH dual-responsive supramolecular vesicles that have a potential to serve as drug nanocarriers to enable controlled drug
- delivery [28]. These findings therefore opened up the possibility for supramolecular chemotherapy based on TBTQ derivatives. However, the use of TBTQ derivatives as hosts to directly encapsulate drugs by forming host–guest complexes has not been reported. In this paper, we report a new water-soluble
Cryogels: recent applications in 3D-bioprinting, injectable cryogels, drug delivery, and wound healing
Beilstein J. Org. Chem. 2021, 17, 2553–2569, doi:10.3762/bjoc.17.171
- cell proliferation and waste exchange, e.g., in a scaffold for tissue engineering applications [3]. Novel biomedical and biotechnical applications of cryogels can also be found in controlled drug delivery, carriers for cell immobilization, sensors, bioseparation, purification, and wound dressing [4][5
Probing of local polarity in poly(methyl methacrylate) with the charge transfer transition in Nile red
Beilstein J. Org. Chem. 2019, 15, 2552–2562, doi:10.3762/bjoc.15.248
- -controlled drug delivery systems [4][6][7][8][9][10], as well as dynamics of polymers at interfaces [11]. To be able to understand local properties of polymers, in particular in nanoenvironments of polymeric vesicles (polymersomes), comprising a hydrophilic corona and a hydrophobic wall [1][12], or in
Morphology-tunable and pH-responsive supramolecular self-assemblies based on AB2-type host–guest-conjugated amphiphilic molecules for controlled drug delivery
Beilstein J. Org. Chem. 2019, 15, 1925–1932, doi:10.3762/bjoc.15.188
- -responsive supramolecular self-assemblies have been constructed, the controlled drug delivery induced by morphology transitions of these supramolecular self-assemblies on the basis of host–guest-conjugated monomers (HGCMs) are few reported. In this paper, the self-assembly behaviors of AB2-type HGCMs, e.g
- varied morphology could inhibit cancer cell proliferation, indicating their potential application in the field of drug delivery. Keywords: β-cyclodextrin; controlled drug delivery; host–guest interaction; stimuli-responsive; supramolecular self-assemblies; Introduction Supramolecular self-assemblies
- results further certified that the fast intracellular drug-release process of DOX-loaded FSSAs provided a large intracellular drug dose and high cytotoxicity. All these results suggested that DOX-loaded FSSAs presented a potential application in controlled drug delivery. Intracellular uptake of drug
Host–guest interactions between p-sulfonatocalix[4]arene and p-sulfonatothiacalix[4]arene and group IA, IIA and f-block metal cations: a DFT/SMD study
Beilstein J. Org. Chem. 2019, 15, 1321–1330, doi:10.3762/bjoc.15.131
- ligands with novel features. They have found various applications in chemical [5], analytical [6][7][8][9], and engineering materials fields (self-assembling monolayers, surfactants, sensors [10][11]), in polymer synthesis [12][13], controlled drug-delivery systems [14], and so on, besides the biochemical
Nanoreactors for green catalysis
Beilstein J. Org. Chem. 2018, 14, 716–733, doi:10.3762/bjoc.14.61
- crystalline domains. The nanogels display excellent swelling behavior and are shape resistant [43][110]. Due to these unique properties they have mostly been studied as materials in biomedical applications such as controlled drug delivery [111]. Nanogels show promise as nanoreactors as they not only are
Exploring mechanochemistry to turn organic bio-relevant molecules into metal-organic frameworks: a short review
Beilstein J. Org. Chem. 2017, 13, 2416–2427, doi:10.3762/bjoc.13.239
- ], luminescence [67], non-linear optics [68] and magnetism [69], as well as contrast agents for magnetic resonance imaging (MRI) [70] and as drug carriers in systems for controlled drug delivery and release [64][71][72][73][74][75][76][77][78][79][80]. Also under development are new systems with potential use in
- centers, in order to obtain compounds with enhanced biological properties. New metal-organic frameworks, BioMOFs, for the use of controlled drug delivery and/or release or other biological applications, were successfully synthesized either by direct incorporation of the bioactive molecule in the framework
β-Cyclodextrin- and adamantyl-substituted poly(acrylate) self-assembling aqueous networks designed for controlled complexation and release of small molecules
Beilstein J. Org. Chem. 2017, 13, 1879–1892, doi:10.3762/bjoc.13.183
- dependent upon the structure of the dye, and the structure of the network and its viscosity. Potentially, these systems form the basis for the development of controlled drug delivery systems for topical and wound applications, where the factors for drug release are likely to be similar to those controlling
Synthesis and characterization of a new photoinduced switchable β-cyclodextrin dimer
Beilstein J. Org. Chem. 2014, 10, 2874–2885, doi:10.3762/bjoc.10.304
- well-defined structure, low toxicological or pharmacological activity, and good solubility in water. For example, the inclusion of active substances in CDs can reduce their undesirable storage or metabolism degradation, which has led research on CDs to focus on controlled drug delivery [4]. In the food
Pyridinium based amphiphilic hydrogelators as potential antibacterial agents
Beilstein J. Org. Chem. 2010, 6, 859–868, doi:10.3762/bjoc.6.101
- ; hydrogel; pyridinium; self-assembly; Introduction Gels are an outstanding group of soft materials lying at the interface of solid and liquid, and find numerous applications in various fields including tissue engineering, biosensors, food processing, cosmetics, photography, controlled drug delivery etc. [1
Novel multi-responsive P2VP-block-PNIPAAm block copolymers via nitroxide-mediated radical polymerization
Beilstein J. Org. Chem. 2010, 6, 756–765, doi:10.3762/bjoc.6.89
- aqueous solution, the block copolymers form so called schizophrenic micelles. The hydrodynamic radius Rh of these micelles associated with pH values and temperature was analyzed by dynamic light scattering (DLS). Such kind of block copolymers has potential for many applications, such as controlled drug
- delivery systems. Keywords: block copolymers; N-isopropylacrylamide; nitroxide-mediated radical polymerization; stimuli-responsive polymers; 2-vinylpyridine; Introduction Functional polymers have attracted much attention because of their technological and scientific importance. Polymers, which respond
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